Advances in the Treatment of Myelofibrosis: Clinical Trial Data of Next Generation Therapeutics – Enduring Webcast

Description

Program Description

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This activity enduring webcast addresses advancements in managing patients with myelofibrosis (MF), including symptom recognition, prognostic risk scoring, and next-generation therapeutics for the treatment of MF.

The program will focus on the following:

MF – Myelofibrosis (MF) is a myeloproliferative neoplasm (MPN) characterized by clonal hematopoietic cell expansion with bone marrow fibrosis.

• Pathophysiology of MF
• Symptomology of MF based on myeloproliferative neoplasm symptom assessment (MPN-SAF)
• Prognostic scoring systems and risk assessment based on IPSS, DIPSS+, MIPSS70, Genetically Inspired IPSS, Myelofibrosis secondary to PV, and ET-prognostic model (MYSEC-PM)
• Molecular profiling of MF – Molecular profiling, cytogenetic and molecular characteristics.
• Prognostic scoring systems and risk assessment based on IPSS, DIPSS+, MIPSS70, Genetically Inspired IPSS, Myelofibrosis secondary to PV, and ET-prognostic model (MYSEC-PM)

Treatment Options for MF – NCCN guideline-directed treatment strategies for MF with JAK inhibitors and a first-in-class telomerase inhibitor.

• JAK Inhibitors
  • Ruxolitinib
  • Fedratinib
  • Pacritinib
• Newer Therapies – Ongoing Clinical Trials
  • PIM1 Kinase Inhibitor
    • Nuvisertib
  • Telomerase Inhibitor
    • Imetelstat (GRN163L)
  • Bromodomain and extraterminal domain (BET) inhibitor (BETi)
    • Pelabresib

Symptomatic patients with anemia and myelofibrosis

• Momelotinib, an activin A receptor type 1, and JAK1 and JAK2 have shown symptom, spleen, and anemia benefits in patients with MF
• Navitoclax (NAV) is an oral, small-molecule inhibitor of BCL-XL and BCL-2 that has a synergistic effect when used in combination with JAK inhibitors

Intended Audience

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Medical oncologists, pathologists, physician assistants, nurse practitioners, nurses, and other healthcare professionals who treat patients with myelofibrosis.

Commercial Support

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Supported by educational grants from Geron Corporation and Incyte Corporation