Immune Checkpoint and BRAF/MEK Inhibitor- directed Therapies for Advanced Melanoma – Enduring Webcast

Description

Program Description

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Treatment options for advanced-stage melanoma have improved dramatically with the introduction of immune checkpoint inhibitors and BRAF and MEK inhibitors. Blocking programmed death 1 (PD-1) in melanoma may enhance the durability of anti-tumor responses induced by the combined inhibition of BRAF and MEK. The presence of shared epitopes (e.g., troponin, desmin, and myosin) between melanoma cells and myocardium is proposed as the primary mechanism of ICI-induced myocarditis. In contrast to ICI-related cardiac irAEs, BRAFi/MEKi mediated cardiac adverse events are due to the critical role of the Ras-Raf-MEK-ERK signaling in the survival of cardiomyocytes. With the emerging application of ICI-BRAFi/MEKi combinations, differentiating between these two types of cardiotoxicities will become essential for appropriate patient management.

Intended Audience

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Oncologists, nurse practitioners, physician assistants, and nurses.

Commercial Supporter

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This activity is supported by an educational grant from Merck Sharp & Dohme.